High-Pressure Transformations in Natural Product Synthesis

This review summarizes the application of high-pressure chemistry in natural product synthesis. By highlighting reactions that could not be promoted by conventional means but that proceed readily under high-pressure conditions, we intend to disclose the benefits of high-pressure-mediated reactions for organic transformations. The individual syntheses are classified by the reaction type of the key step and are discussed briefly. 1 Introduction 2 Cycloaddition Reactions 2.1 Diels–Alder Reactions 2.2 Inverse-Electron-Demand Diels–Alder Reactions 2.3 Hetero-Diels–Alder Reactions 3 Miscellaneous Reactions 4 Conclusion