The Effect of Thiocyanate Concentration on Thiocyanate Distribution and Excretion

It has been observed in rats that the measured volume of distribution of thiocyanate is decreased by high plasma concentrations of thiocyanate, and that large doses of thiocyanate have a faster rate of disappearance from the plasma than does endogenous thiocyanate at normal concentrations. These observations are interpreted as results of (i) the saturation of thiocyanate-concentrating compartments, and (ii) the inability of the kidney tubule to reabsorb large amounts of filtered thiocyanate.