In this era of digital transformation, supply chains are transitioning from linear, disjointed chains into interconnected networks that require agility, transparency, and social responsibility. “How to Build Supply Chains That Are Resilient and Sustainable in the Digital Transformation Era” dives into how organizations can leverage new and innovative technologies to design resilient supply chains that not only weather the storm but also connect to our planet and our people going forward. This chapter covers the fundamental principles and novel methodologies of resilience and sustainability as the key to coping with risk and disruptions in global Supply Chain Management (SCM) through the digital revolution via the prospective of digital economy and solutions provided by digital tools like Artificial Intelligence (AI), Internet of Things (IoT), blockchain, and big data analytics. Driven by mounting challenges like climate change, resource deplete on, and global volatility, companies are pushed to rethink their supply chain approaches. This chapter offers a structured framework for linking Environmental, Social, And Governance (ESG) objectives to digital innovation to drive operational efficiency, build trust with stakeholders, and mitigate risk. It also explores how smart supply networks can respond to crises and facilitate circular economic practices, with practical examples from different industries. This chapter is a good reference for researchers, industrialists, and policy-makers eager to grasp the insights and practices of sustainable and resilient supply chain strategies in a digital world. Its cross-functional perspective brings together technology, strategy, and sustainability as part of one clear trajectory for planning supply chains for the future.