血管性血友病因子
细胞生物学
内皮
化学
内皮干细胞
微泡
小泡
生物
发病机制
遗传流行病学
内皮功能障碍
分泌泡
血管
HEK 293细胞
细胞外小泡
遗传变异
作者
Paula Reventun,Pablo Toledano-Sanz,María Delgado-Marín,Maria Viskadourou,D. Brian Foster,Paul S. de Vries,Maria Sabater‐Lleal,Nunzio Alcharani,Claudia González-Cucharero,William O. Osburn,Alanna C. Morrison,Alisa S. Wolberg,Nicholas L. Smith,Marios Arvanitis,Alanna C. Morrison,Charles J. Lowenstein
标识
DOI：10.1161/atvbaha.125.323000
摘要
Taken together, our data demonstrate that RAB5C regulates VWF release in part through SNAP29 control of vesicle trafficking in endothelial cells. These findings validate genetic epidemiology data linking RAB5C to VWF levels in humans and provide new insights into the molecular mechanisms regulating VWF exocytosis.
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(2025-6-4)
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