ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

), formulated with DOTAP to enhance autophagic activity and promote lysosomal trafficking. This combined strategy synergistically amplified STING degradation, leading to potent suppression of inflammatory signaling, mitigation of tissue damage, and promotion of tissue regeneration across multiple disease models. These findings illustrate a cooperative material-based strategy that enhances autophagy and enables targeted protein degradation, positioning lysosome-targeting degraders as a promising translational modality for immunomodulatory therapy.