对映选择合成
位阻效应
化学
芳基
联吡啶
组合化学
催化作用
试剂
镍
卤代芳基
功能群
卤化物
2,2'-联吡啶
还原消去
钯
有机化学
立体化学
晶体结构
聚合物
烷基
作者
Shuai Zhang,Saima Perveen,Yizhao Ouyang,Liang Xu,Tao Yu,Min Zhao,Linghua Wang,Peidong Song,Pengfei Li
标识
DOI:10.1002/anie.202117843
摘要
A new class of chiral 2,2'-bipyridine ligands, SBpy, featuring minimized short-range steric hindrance and structural tunability was rationally designed and developed, and the effectiveness was demonstrated in the first highly enantioselective Ni-catalyzed addition of aryl halides to aldehydes. In comparison with known approaches using preformed aryl metallic reagents, this reaction is more step-economical and functional group tolerant. The reaction mechanism and a model of stereocontrol were proposed based on experimental and computational results.
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