To present clinical findings of ophthalmic artery occlusion, a devastating ocular complication because of forehead autologous fat injection.Retrospective study of three eyes of three patients whereby ophthalmic artery occlusion and/or hemiplegia occurred after forehead autologous fat injection in China.All patients suffered severe ocular pain, vomiting, and vision loss immediately after the injections and had unilateral permanent blindness.Physicians performing cosmetic facial surgery involving autologous fat injection need to be aware of this potential risk and should inform the patient before the surgery.