医学
钙化
内科学
心脏病学
四分位数
尿酸
高尿酸血症
冠状动脉疾病
接收机工作特性
钙化积分
动脉
风险因素
弗雷明翰风险评分
疾病
置信区间
冠状动脉钙
作者
Ji Eun Jun,You-Bin Lee,Seung‐Eun Lee,Ji Yeon Ahn,Gyuri Kim,Kyu Yeon Hur,Moon‐Kyu Lee,Mi Ra Kang,Jae Hyun Kim
标识
DOI:10.1016/j.atherosclerosis.2018.02.014
摘要
Background and aims Hyperuricemia was frequently noted in subjects with a high risk of cardiovascular disease (CVD). This study aimed to elucidate whether serum uric acid (SUA) is associated with development of moderate coronary artery calcification in generally healthy adults. Methods A total of 9297 subjects underwent multidetector CT for the evaluation of CAC at least two times during their annual health examinations. Among them, 4461 participants without CVD history and who had no (scores 0) or minimal CAC (scores 1–10) in their first examination were enrolled. The association between SUA as a continuous and categorical variable and development of moderate coronary artery calcification (CAC score > 100) was assessed by Cox regression analysis. Receiver-operating characteristic (ROC) curves were constructed to investigate the diagnostic efficacy of SUA. Results During a median follow-up of 4.1 years, 131 incident cases of moderate calcification developed. Baseline SUA concentration was significantly higher in subjects with progression to moderate coronary artery calcification (6.6 ± 1.3 vs. 5.8 ± 1.3 mg/dL, p < 0.001). SUA as a continuous variable (per 1 mg/dL) and divided into quartiles was positively associated with a higher risk of development of moderate calcification after adjustment for conventional CVD risk factors. The addition of SUA to the conventional CVD risk factors improved the predictive power for development of moderate coronary artery calcification. Conclusions SUA was an independent predictor for development of moderate coronary artery calcification in subjects with no or minimal calcification.
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