鞭毛蛋白
免疫系统
先天免疫系统
沙门氏菌
获得性免疫系统
生物
微生物学
TLR5型
鞭毛
抗体
免疫学
细菌
Toll样受体
遗传学
作者
Rosa Marı́a Salazar-González,Stephen J. McSorley
标识
DOI:10.1016/j.imlet.2005.05.004
摘要
Bacterial flagellins are important components of the motility apparatus used by many microbial pathogens. These proteins are also targets of the innate and adaptive immune response of the host during infection and autoimmune disease. Flagellin interacts with TLR-5 and leads to the generation of a pro-inflammatory response and activation of host dendritic cells in vivo. Furthermore, flagellin is recognized by antibody and CD4 T cells responses during Salmonella infection. Here, we review recent developments in the understanding of flagellin interactions with the host immune system.
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