The effect of inclusion of aluminium hydroxide in alginate-containing raft-forming antacids

The effect of the inclusion of aluminium hydroxide on the neutralization profiles and raft strength of alginate-based antacid formulations was investigated using in vitro techniques. The results indicate that the aluminium hydroxide remains associated with the raft material and does not neutralize the acid layer below. The physical strength of the raft produced by the formulation on reaction with acid was reduced by the inclusion of aluminium hydroxide.