转移
细胞融合
生物
表型
癌细胞
融合基因
骨髓
癌症
癌症研究
癌症转移
病理
细胞
免疫学
基因
医学
遗传学
作者
John M. Pawelek,Ashok Chakraborty
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2008-05-01
卷期号:8 (5): 377-386
被引量:290
摘要
The causes of metastasis remain elusive despite vast information on cancer cells. We posit that cancer cell fusion with macrophages or other migratory bone marrow-derived cells (BMDCs) provides an explanation. BMDC-tumour hybrids have been detected in numerous animal models and recently in human cancer. Molecular studies indicate that gene expression in such hybrids reflects a metastatic phenotype. Should BMDC-tumour fusion be found to underlie invasion and metastasis in human cancer, new approaches for therapy would surely follow.
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