化学
取代基
诱导剂
干扰素
体外
立体化学
烷氧基
戒指(化学)
烷基
结构-活动关系
药理学
生物化学
有机化学
病毒学
基因
生物
医学
作者
Kosaku Hirota,Kazunori Kazaoka,Itaru Niimoto,Hiroshi Kumihara,Hironao Sajiki,Yoshiaki Isobe,Haruo Takaku,Masanori Tobe,Haruhisa Ogita,Tetsuhiro Ogino,Shinji Ichii,and Ayumu Kurimoto,Hajime Kawakami
摘要
9-Benzyl-8-hydroxyadenine (6) was found to possess interferon-inducing activity in vitro as a lead compound. Although replacement of the 9-benzyl group of 6 did not improve the activity, the introduction of a substituent such as alkyl, alkylthio, alkylamino, and alkoxy groups into the 2-position of the adenine ring resulted in a remarkable increase in the activity. The 2-alkylthio (30-32), 2-butylamino (41), and 2-butoxy (47) analogues indicated the highest activities by oral administration to mice.
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