免疫疗法
抗原
免疫
免疫系统
免疫学
生物
主动免疫治疗
细胞毒性T细胞
调节性T细胞
接种疫苗
癌症免疫疗法
T细胞
癌症研究
白细胞介素2受体
体外
遗传学
摘要
Tumours express a range of antigens, including self-antigens. Regulatory T cells are crucial for maintaining T-cell tolerance to self-antigens. Regulatory T cells are thought to dampen T-cell immunity to tumour-associated antigens and to be the main obstacle tempering successful immunotherapy and active vaccination. In this Review, I consider the nature and characteristics of regulatory T cells in the tumour microenvironment and their potential multiple suppressive mechanisms. Strategies for therapeutic targeting of regulatory T cells and the effect of regulatory T cells on current immunotherapeutic and vaccine regimens are discussed.
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