Sesquiterpenoids and Lignans from Ligularia virgaurea spp. oligocephala

From the BuOH extract of the whole plant of Ligularia virgaurea spp. oligocephala, a series of sesquiterpenes, sesquiterpene glycosides, and lignan glycosides were isolated, including the three new compounds (1α)-1-hydroxy-8-oxo-eremophila-6,9-dien-12-oic acid (1), 8-[(β-D-glucopyranosyl)oxy]eremophila-1(10),8,11-trien-2-one (2), and 4-[(β-D-glucopyranosyl)oxy]pinoresinol (4). Their structures were elucidated by 1D- and 2D-NMR as well as HR-ESI-MS analyses, and by comparison of the spectroscopic data with those reported for structurally related compounds.