趋化因子
毛细支气管炎
免疫学
医学
呼吸道
干扰素
呼吸系统
病毒
CXCL11型
CXCL10型
免疫系统
病毒学
内科学
出处
期刊:PubMed
日期:2015-01-01
卷期号:166 (3): e203-8
被引量:1
摘要
The importance of the Type-1 helper (Th1) chemokines in RSV (respiratory syncytial virus) infection has been shown by several studies, in animal models, and in humans. The production of Th1 chemokines within the lower respiratory tract has been shown in patients with RSV bronchiolitis, particularly chemokine (C-X-C motif) ligand (CXCL)10/interferon-γ-inducible protein 10 (IP-10), whose plasma levels were markedly elevated in acute infection. RSV fusion (F) or large (G) protein treatment of fully differentiated primary normal human bronchial epithelial cells induces apical secretion of IP-10 and other chemokines. Exposure to environmental tobacco smoke is associated with an increase in the frequency and severity of respiratory infections, including bronchiolitis, and inhibited RSV-induced Interferon (IFN)-α in plasmacytoid dendritic cells as well as the release of IP-10. Vitamin D in airway epithelium decreases RSV induction of NF-kappaB-driven genes such as IFN-β and IP-10. These findings highlight the role for the IP-10: chemokine (C-X-C motif) receptor (CXCR)3 signaling axis in RSV-infection by recruiting virus-specific T cells into the lung and promoting viral clearance.
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