Dual Proton/Anion Binding Through Reciprocal Allostery in Platinum(II) Lantern‐Shaped Cages

Abstract Reciprocal allosteric regulation, where binding events influence each other simultaneously, is a key target for supramolecular chemists designing biomimetic systems. Platinum(II) lantern‐shaped cages, formed from a series of ligands bearing central protonatable sites of varied basicity through rational tuning of the backbone, featured nuanced dual action host‐guest chemistry. This reveals the first example of reciprocal allostery in a supramolecular system, between protonation and anion binding. Switching studies were conducted using acid/base and silver/chloride stimuli, with single and multi‐anion systems.