胞浆
内化
小干扰RNA
化学
细胞内
树枝状大分子
细胞生物学
RNA干扰
聚赖氨酸
肽
核糖核酸
谷胱甘肽
下调和上调
内体
细胞穿透肽
生物物理学
癌细胞
生物化学
基因沉默
A549电池
纳米载体
细胞
翻译(生物学)
转染
寡肽
作者
Dandan Zhu,Huiling Zhu,Yaoyun Yu,Junyue Zheng,Xianhui Lin,Huimin Cheng,Aoxue Mei,Ming Chen,Yun Li,Haijuan Dong,Jiehua Zhou,Juan LIU,Xiaoxuan Liu
摘要
achieved substantial reductions in tumor growth and PLK1 expression while exhibiting minimal systemic toxicity. This study highlights a synergistic approach utilizing bola-amphiphilic peptide dendrimers for tumor-specific and cytosolic siRNA delivery, leveraging membrane-thiol interactions and intracellular GSH-triggered siRNA release.
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