喷雾干燥
喷嘴
PLGA公司
聚合物
甘露醇
喷嘴
微粒
色谱法
化学工程
材料科学
化学
集聚经济
纳米技术
有机化学
纳米颗粒
工程类
物理
热力学
作者
Shigeyuki Takada,Yoshiaki Uda,Hajime Toguchi,Yasuaki Ogawa
出处
期刊:PubMed
日期:1995-07-01
卷期号:49 (4): 180-4
被引量:19
摘要
Copoly (dl-lactic/glycolic acid) microparticles for sustained release of a water-soluble drug (Thyrotropin releasing hormone: TRH) were prepared by a spray drying method. A higher entrapment ratio was achieved with the spray drying method with the in-water drying method. In order to avoid agglomeration of the microparticles, a double-nozzle spray drying method was designed using mannitol as an anti-adherent. The surface of the spray-dried microparticles was coated with mannitol, and the extent of agglomeration was decreased. Acetonitrile was the most suitable solvent for microencapsulation using the double-nozzle spray drying method because the initial burst of TRH from the microparticles during the first day was the smallest. When PLGA with a weight-average molecular weight of 14,000 was used, constant release of TRH continued for one month with a small initial burst. In conclusion, the production of biodegradable microparticles by the double-nozzle spray drying method appears to be an attractive alternative to conventional microencapsulation methods.
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