骨髓纤维化
医学
巨球蛋白血症
华登氏巨球蛋白血症
骨髓
伊布替尼
美罗华
淋巴浆细胞淋巴瘤
内科学
胃肠病学
淋巴瘤
肿瘤科
慢性淋巴细胞白血病
白血病
多发性骨髓瘤
作者
Ryohei Nawata,Akiko Sugiyama,Keisuke Harada,Kenji Shinohara,Toshiaki Yujiri
出处
期刊:PubMed
日期:2019-01-01
卷期号:60 (8): 903-909
标识
DOI:10.11406/rinketsu.60.903
摘要
A 78-year-old man with anemia (Hb 9.6 g/dl) and elevated serum immunoglobulin M (IgM 3,577 mg/dl) levels was referred to our hospital. Bone marrow aspiration yielded a dry tap, and bone marrow biopsy revealed the infiltration of CD20 positive lymphoplasmacytic lymphoma cells and myelofibrosis. The patient was diagnosed with Waldenström's macroglobulinemia complicated with myelofibrosis. TGF-β plasma concentration was elevated. Further, after chemotherapy with bendamustine and rituximab, remission of both Waldenström's macroglobulinemia and myelofibrosis was achieved, and TGF-β levels normalized. MYD88 L265P mutation was detected using highly sensitive digital PCR, which compared with currently used direct PCR product sequencing, has a superior sensitivity. The use of digital PCR has additional advantages toward MYD88 L265P detection, particularly when the available amount of sample DNA is limited owing to myelofibrosis.
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