再狭窄
儿茶酚
涂层
内皮
表面工程
胺气处理
裸金属
金属
表面改性
支架
医学
材料科学
纳米技术
生物医学工程
化学工程
化学
内科学
冶金
外科
有机化学
工程类
作者
Ying Yang,Xiancheng Zhang,Juan Wang,Qiufen Tu,Long Bai,Kaiqin Xiong,Hua Qiu,Xin Zhao,Manfred F. Maitz,Huaiyu Wang,Xiangyang Li,Qiang Zhao,Yin Xiao,Nan Huang,Zhilu Yang
出处
期刊:Research
[AAAS00]
日期:2020-01-01
卷期号:2020
被引量:67
标识
DOI:10.34133/2020/9203906
摘要
Stenting is currently the major therapeutic treatment for cardiovascular diseases. However, the nonbiogenic metal stents are inclined to trigger a cascade of cellular and molecular events including inflammatory response, thrombogenic reactions, smooth muscle cell hyperproliferation accompanied by the delayed arterial healing, and poor reendothelialization, thus leading to restenosis along with late stent thrombosis. To address prevalence critical problems, we present an endothelium-mimicking coating capable of rapid regeneration of a competently functioning new endothelial layer on stents through a stepwise metal (copper)-catechol-(amine) (MCA) surface chemistry strategy, leading to combinatorial endothelium-like functions with glutathione peroxidase-like catalytic activity and surface heparinization. Apart from the stable nitric oxide (NO) generating rate at the physiological level ( 2.2×10−10 mol/cm2/min lasting for 60 days), this proposed strategy could also generate abundant amine groups for allowing a high heparin conjugation efficacy up to ∼1 μ g/cm 2 , which is considerably higher than most of the conventional heparinized surfaces. The resultant coating could create an ideal microenvironment for bringing in enhanced anti-thrombogenicity, anti-inflammation, anti-proliferation of smooth muscle cells, re-endothelialization by regulating relevant gene expressions, hence preventing restenosis in vivo. We envision that the stepwise MCA coating strategy would facilitate the surface endothelium-mimicking engineering of vascular stents and be therefore helpful in the clinic to reduce complications associated with stenosis.
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