Integrative proteomics of prostate cancer

Large-scale, genome-wide sequencing efforts have comprehensively characterized genomic and transcriptomic landscape of prostate cancer, revealing recurrently altered genes as well as substantial heterogeneity in cancer-driving mutations. Recently, integrative proteogenomic studies of prostate tumor samples have demonstrated that, in fact, there is a poor correlation between alterations in the genome and transcriptome compared with the proteomic profiles, suggesting that a large fraction of the accrued changes at nucleotide levels are insignificant with respect to protein functions. The proteomic profiling has provided an enhanced view of deregulated pathways during development of prostate cancer and formation of castration resistance. These results underline the importance of proteogenomic analyses to gain better understanding of the cancer phenotypes and to develop more effective therapeutic strategies.