Efficient and Chemoselective Amidation of β ‐Carboline Carboxylic Acids

Abstract A series of β ‐carboline amides has been synthesized in one‐pot reaction via coupling between an acid and an amine in the presence of HBTU/Et 3 N. This mild amidation reaction undergoes efficiently and chemoselectively. Bioactivity studies indicate that the β ‐carboline amide derivatives exhibit neuroprotective activity and might be developed to be lead compounds for anti‐stroke agents.