The GTEx Consortium atlas of genetic regulatory effects across human tissues

基因遗传学遗传变异 RNA剪接基因表达调控人类遗传变异基因表达计算生物学生物人类基因组基因组核糖核酸

作者

François Aguet,Shankara Anand,Kristin Ardlie,Stacey Gabriel,Gad Getz,Aaron Graubert,Kane Hadley,Robert E. Handsaker,Katherine Huang,Seva Kashin,Xiao Li,Daniel G. MacArthur,Samuel R. Meier,Jared L. Nedzel,Duyen T. Nguyen,Ayellet V. Segrè,Ellen Todres,Brunilda Balliu,Alvaro Barbeira,Alexis Battle,Rodrigo Bonazzola,Andrew Brown,Christopher Brown,Stephane E. Castel,Donald F. Conrad,Daniel J. Cotter,Nancy J. Cox,Sayantan Das,Olivia M. de Goede,Emmanouil T. Dermitzakis,Jonah Einson,Barbara E. Engelhardt,Eleazar Eskin,Tiffany Eulalio,Nicole M. Ferraro,Elise D. Flynn,Laure Frésard,Eric R. Gamazon,Diego Garrido-Martín,Nicole R. Gay,Michael J. Gloudemans,Roderic Guigó,Andrew R. Hame,Yuan He,Paul Hoffman,Farhad Hormozdiari,Lei Hou,Hae Kyung Im,Brian Jo,Silva Kasela,Manolis Kellis,Sarah Kim-Hellmuth,Alan Kwong,Tuuli Lappalainen,Xin Li,Yanyu Liang,Serghei Mangul,Pejman Mohammadi,Stephen B. Montgomery,Manuel Muñoz-Aguirre,Daniel Nachun,Andrew B. Nobel,Meritxell Oliva,YoSon Park,Yongjin Park,Princy Parsana,Abhiram Rao,Ferrán Reverter,John M. Rouhana,Chiara Sabatti,Ashis Saha,Matthew Stephens,Barbara E. Stranger,Benjamin J. Strober,Nicole A. Teran,Ana Viñuela,Gao Wang,Xiaoquan Wen,Fred A. Wright,Valentin Wucher,Yuxin Zou,Pedro G. Ferreira,Gen Li,Marta Melé,Esti Yeger‐Lotem,Mary E. Barcus,Debra Bradbury,Tanya Krubit,Jeffrey A. McLean,Liqun Qi,Karna Robinson,Nancy Roche,Anna Marie Smith,Leslie H. Sobin,David E. Tabor,Anita H. Undale,Jason Bridge,Lori E. Brigham,Barbara A. Foster,Bryan M. Gillard,Richard Hasz,Marcus Hunter,Christopher Johns,Mark P. Johnson,Ellen Karasik,Gene Kopen,William F. Leinweber,Alisa McDonald,Michael T. Moser,Kevin Myer,Kimberley D. Ramsey,Brian Roe,Saboor Shad,Jeffrey A. Thomas,Gary Walters,Michael Washington,J. Gary Wheeler,Scott D. Jewell,Daniel C. Rohrer,Dana R. Valley,David A. Davis,Deborah C. Mash,Philip A. Branton,Laura K. Barker,Heather M. Gardiner,Maghboeba Mosavel,Laura A. Siminoff,Paul Flicek,Maximilian Haeussler,Thomas Juettemann,W. James Kent,Christopher M. Lee,Conner C. Powell,Kate R. Rosenbloom,Magali Ruffier,Dan Sheppard,Kieron Taylor,Stephen J. Trevanion,Daniel R. Zerbino,Nathan S. Abell,Joshua M. Akey,Lin Chen,Kathryn Demanelis,Jennifer A. Doherty,Andrew P. Feinberg,Kasper D. Hansen,Peter F. Hickey,Farzana Jasmine,Lihua Jiang,Rajinder Kaul,Muhammad G. Kibriya,Jin Billy Li,Qin Li,Shin Lin,Sandra E. Linder,Brandon L. Pierce,Lindsay F. Rizzardi,Andrew D. Skol,Kevin S. Smith,M Snyder,J Stamatoyannopoulos,Hua Tang,Meng Wang,Latarsha J. Carithers,Ping Guan,Susan E. Koester,A. Roger Little,Helen M. Moore,Concepcion R. Nierras,Abhi K. Rao,Jimmie B. Vaught,Simona Volpi

出处

期刊：Science [American Association for the Advancement of Science]
日期：2020-09-10 卷期号：369 (6509): 1318-1330 被引量：3441

链接

sciencemag.org handle.net ub.edu nih.gov handle.net upc.edu ac.uk ac.uk ac.uk nih.govdoi.org

标识

DOI：10.1126/science.aaz1776

摘要

The Genotype-Tissue Expression (GTEx) project dissects how genetic variation affects gene expression and splicing.

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The GTEx Consortium atlas of genetic regulatory effects across human tissues

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