石墨烯
氧化物
纳米技术
氧化铁纳米粒子
生物相容性
医学
纳米医学
纳米复合材料
纳米材料
作者
Taicheng Lu,Liying Wei,Xiaoqing Huang,Yin Li,Guo Li,Qixiao Qin,Meishi Pan,Bingling Tang,Xin Pan,Mei Wei,Zhenzhen Nong,Fayan Meng,Xuehua Li
标识
DOI:10.1016/j.msec.2021.112293
摘要
Abstract Due to increased requirements for precision cancer treatment, cancer chemotherapy and combination therapies have gradually developed in the direction of diagnosis and treatment integration. In this study, a non-toxic nano carrier that demonstrates integrated MRI signal enhancing performance, as well as better chemotherapy and photothermal conversion performance, was prepared and characterized. Furthermore, the carrier was used to construct an integrated system of tumor diagnosis and treatment. Our in vitro studies showed that this system has a considerable inhibition effect on tumor cells during the treatment of chemotherapy when combined with PTT, and in vivo studies showed that the system could improve the MRI signal of the tumor site with application of a safe dosage. Thus, this system based on NGO/USPIO has the potential to be a multi-functional nano drug delivery system integrating diagnosis and treatment benefits and applications that are worthy of further research.
科研通智能强力驱动
Strongly Powered by AbleSci AI