已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

A Systematic Literature Review of Injection Site Pain Perception in Adult Patients Treated with Citrate-Free and Citrate-Containing Biologic Agents

医学 安慰剂 观察研究 荟萃分析 系统回顾 科克伦图书馆 随机对照试验 赋形剂 临床试验 梅德林 皮下注射 内科学 药理学 替代医学 病理 政治学 法学
作者
Sophia Junker,Oliver Ebert,R. Bartsch
出处
期刊:Current Rheumatology Reviews [Bentham Science]
卷期号:19 (3): 303-313
标识
DOI:10.2174/1573397118666220829123713
摘要

Objective: To investigate injection site pain (ISP) and other injection site outcomes caused by biologics administered alongside citrate-free (CF) and citrate-containing (CC) formula-tions. Methods: Electronic literature databases (Medline, Embase, and Cochrane Library) were systemati-cally searched for clinical trials and observational studies reporting on injection site outcomes after subcutaneous administration of biologics. Studies with unknown excipient formulations were ex-cluded. The primary outcome was ISP, and secondary outcomes included any other reported injec-tion site reactions (ISRs). Meta-analysis approaches were used to aggregate evidence identified via the conducted systematic literature review. Results: A total of two observational studies, two cross-over/sequential trials, and three head-to-head comparison trials directly comparing CF with CC biologics were identified, as well as seven placebo-controlled trials. Evidence from five of the seven direct comparison studies suggested re-duced pain perception at the injection site when CF formulations were applied. Findings for other ISRs were balanced between both formulations, with slightly favorable results for preparations without citrate. A meta-analysis of placebo-controlled trials found no significant difference between arms with CF formulations and placebo regarding the proportion of patients experiencing ISP (OR 0.62, 95% CI 0.30-1.28). Conclusion: Excipient formulations are rarely specified in studies assessing pain and other ISRs of subcutaneously administered biologics. The available data indicate that subcutaneous administration of biologic agents without citrate may be associated with lower pain perception outcomes compared with treatment using CC formulations. Importantly, ISP is influenced by many factors which may have affected the results. More research is needed to assess how formulation excipients influence ISRs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
1秒前
风趣的茹嫣完成签到 ,获得积分10
2秒前
秋雪瑶应助zq采纳,获得10
3秒前
4秒前
就看最后一篇完成签到 ,获得积分10
4秒前
nnnym完成签到,获得积分10
4秒前
8秒前
子昱完成签到 ,获得积分10
8秒前
和谐续完成签到 ,获得积分10
9秒前
10秒前
wang@163.com完成签到,获得积分20
13秒前
轻松听双发布了新的文献求助10
15秒前
热塑性哈士奇完成签到,获得积分10
17秒前
wang@163.com发布了新的文献求助10
17秒前
lxf_123完成签到,获得积分10
21秒前
xumodehudie完成签到 ,获得积分10
21秒前
24秒前
秋雪瑶应助lsr采纳,获得10
26秒前
ARESCI完成签到,获得积分20
28秒前
zq发布了新的文献求助10
29秒前
Invincible完成签到 ,获得积分10
32秒前
赘婿应助wang@163.com采纳,获得10
32秒前
细水长流完成签到 ,获得积分10
34秒前
zq完成签到,获得积分20
45秒前
星期五完成签到,获得积分10
46秒前
46秒前
头盔小猪完成签到,获得积分10
47秒前
丘比特应助科研通管家采纳,获得10
48秒前
充电宝应助科研通管家采纳,获得10
48秒前
小马甲应助科研通管家采纳,获得10
48秒前
所所应助科研通管家采纳,获得10
48秒前
赘婿应助科研通管家采纳,获得10
48秒前
shinysparrow应助科研通管家采纳,获得10
48秒前
xioabu发布了新的文献求助10
50秒前
klandcy完成签到 ,获得积分10
53秒前
Ya完成签到 ,获得积分10
55秒前
天天快乐应助xioabu采纳,获得10
57秒前
缺牙巴完成签到 ,获得积分10
1分钟前
1分钟前
高分求助中
The three stars each : the Astrolabes and related texts 1070
Manual of Clinical Microbiology, 4 Volume Set (ASM Books) 13th Edition 1000
Sport in der Antike 800
De arte gymnastica. The art of gymnastics 600
少脉山油柑叶的化学成分研究 530
Sport in der Antike Hardcover – March 1, 2015 500
Boris Pesce - Gli impiegati della Fiat dal 1955 al 1999 un percorso nella memoria 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2406286
求助须知:如何正确求助?哪些是违规求助? 2103997
关于积分的说明 5310788
捐赠科研通 1831508
什么是DOI,文献DOI怎么找? 912631
版权声明 560650
科研通“疑难数据库(出版商)”最低求助积分说明 487914