Potential therapeutic effect of Salvia coccinea leaf extract in chronic disorders: Myocardial infarction, cataract, and arthritis in rat

医学 天冬氨酸转氨酶 谷胱甘肽过氧化物酶 氧化应激 关节炎 药理学 肌酸激酶 超氧化物歧化酶 脂质过氧化 乳酸脱氢酶 内科学 内分泌学 谷胱甘肽 心肌梗塞 生物化学 化学 碱性磷酸酶
作者
Arun Sundaramoorthy,Narkunaraja Shanmugam
标识
DOI:10.1016/j.pscia.2023.100017
摘要

Aqueous extract from Salvia coccinea leaf (AESL) has been shown its unique anti-oxidant effect via Nuclear factor (NF)-kappa (κ)B pathway in human monocytic THP-1 cells and pharmacological effect on inflammatory diseases like diabetes in rats. Using AESL, which possess antioxidant activity by scavenging radicals and decreasing oxidative stress, would be a promising strategy for the treatment of other inflammatory disorders like myocardial infarction, arthritis, and cataract. This study was designed to evaluate the ameliorating effects of AESL on isoproterenol (Iso)-induced myocardium infarction (MI), selenite-induced cataractogenesis, and complete Freund's adjuvant-induced arthritic in Wistar rats. In this study, AESL ameliorated pathological changes in Iso-induced MI hear muscles and Electro Cardio Grampattern, 35–80 % protection of the cataractogenesis, and prevented the apoptosis induced by selenite in the rat lens. Both pre and post-treatment of AESL (600 mg/kg, bw) showed no swelling of the joint and, 35 days treatment showed significant prevention against bony destruction as depicted by less narrowing of joint spaces and soft tissue swelling when compared with control rats. Oral administration of AESL inhibited the Iso-induced increase in serum and myocardial lipid peroxidation, aspartate transaminase, alanine transaminase, creatine kinase, troponin-I, and troponin-T, and lactate dehydrogenase of myocardium infarction rats. Significant increases in the activity of superoxide dismutase, catalase, glutathione peroxidase, and a reduced level of glutathione, were observed in AESL treated cataract rat lens. The results demonstrate that AESL is useful in, in addition to diabetes, controlling myocardium infarction, cataracts, and arthritis.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
云宝完成签到 ,获得积分10
刚刚
李牛牛完成签到,获得积分10
2秒前
3秒前
树下猫完成签到,获得积分10
3秒前
CodeCraft应助美女采纳,获得10
3秒前
yar应助加百莉采纳,获得10
4秒前
打打应助yee采纳,获得10
6秒前
跳跃的航空完成签到,获得积分10
7秒前
烟花应助豆浆来点蒜泥采纳,获得10
12秒前
vict完成签到,获得积分10
13秒前
13秒前
KSAcc完成签到,获得积分20
13秒前
李健应助科研通管家采纳,获得30
13秒前
欢喜橙子应助科研通管家采纳,获得10
13秒前
13秒前
耍酷亦玉应助科研通管家采纳,获得50
14秒前
JamesPei应助科研通管家采纳,获得10
14秒前
斯文败类应助科研通管家采纳,获得10
14秒前
CodeCraft应助科研通管家采纳,获得10
14秒前
ZeKaWa应助科研通管家采纳,获得10
14秒前
三七完成签到 ,获得积分10
14秒前
14秒前
上官若男应助科研通管家采纳,获得10
14秒前
赘婿应助科研通管家采纳,获得30
14秒前
ZeKaWa应助科研通管家采纳,获得10
14秒前
ZeKaWa应助科研通管家采纳,获得10
15秒前
Owen应助科研通管家采纳,获得10
15秒前
天天快乐应助科研通管家采纳,获得10
15秒前
15秒前
桐桐应助Kevin Huang采纳,获得30
15秒前
15秒前
丘比特应助科研通管家采纳,获得10
15秒前
LZW完成签到,获得积分10
15秒前
热情千风完成签到,获得积分10
16秒前
16秒前
是你啊完成签到,获得积分10
17秒前
张彩发布了新的文献求助10
17秒前
是羽曦呀应助做好胶水采纳,获得10
20秒前
22秒前
充电宝应助诗轩采纳,获得10
23秒前
高分求助中
【请各位用户详细阅读此贴后再求助】科研通的精品贴汇总(请勿应助) 10000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
求 5G-Advanced NTN空天地一体化技术 pdf版 500
International Code of Nomenclature for algae, fungi, and plants (Madrid Code) (Regnum Vegetabile) 500
Maritime Applications of Prolonged Casualty Care: Drowning and Hypothermia on an Amphibious Warship 500
Comparison analysis of Apple face ID in iPad Pro 13” with first use of metasurfaces for diffraction vs. iPhone 16 Pro 500
Towards a $2B optical metasurfaces opportunity by 2029: a cornerstone for augmented reality, an incremental innovation for imaging (YINTR24441) 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4065183
求助须知:如何正确求助?哪些是违规求助? 3603756
关于积分的说明 11445834
捐赠科研通 3326359
什么是DOI,文献DOI怎么找? 1828747
邀请新用户注册赠送积分活动 898896
科研通“疑难数据库(出版商)”最低求助积分说明 819394