双金属片
过氧化氢
癌细胞
癌症治疗
化学
光子上转换
纳米技术
细胞内
纳米复合材料
光动力疗法
癌症
催化作用
材料科学
生物化学
医学
离子
有机化学
内科学
作者
Jun Zhong,Xiang Zheng,Yuan Wen,Yuewei Li,Jianting Zhang,Ranjith Kumar Kankala,Shibin Wang,Ai‐Zheng Chen
摘要
Abstract The inadequate quantity of hydrogen peroxide (H2O2) in cancer cells promptly results in the constrained success of chemodynamic therapy (CDT). Significant efforts made throughout the years; nevertheless, researchers are still facing the great challenge of designing a CDT agent and securing H2O2 supply within the tumor cell. In this study, taking advantage of H2O2 level maintenance mechanism in cancer cells, a nanozyme-based bimetallic metal-organic frameworks (MOFs) tandem reactor is fabricated to elevate intracellular H2O2 levels, thereby enhancing CDT. In addition, under near-infrared excitation, the upconversion nanoparticles (UCNPs) loaded into the MOFs can perform photocatalysis and generate hydrogen, which increases cellular susceptibility to radicals induced from H2O2, inhibits cancer cell energy, causes DNA damages and induces tumor cell apoptosis, thus improving CDT therapeutic efficacy synergistically. The proposed nanozyme-based bimetallic MOFs-mediated CDT and UCNPs-mediated hydrogen therapy act as combined therapy with high efficacy and low toxicity.
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