生物
加压器
抄写(语言学)
生物钟
昼夜节律
基因沉默
细胞生物学
核受体
小异二聚体伴侣
遗传学
肝受体同系物-1
基因
转录因子
振荡基因
细菌昼夜节律
神经科学
语言学
哲学
作者
Kexin Zhu,Isaac J. Celwyn,Dongyin Guan,Xiao Yang,Xiang Wang,Wenxiang Hu,Chunjie Jiang,Lan Cheng,Rafael Casellas,Mitchell A. Lazar
出处
期刊:Molecular Cell
[Elsevier]
日期:2023-10-01
卷期号:83 (19): 3457-3469.e7
被引量:8
标识
DOI:10.1016/j.molcel.2023.09.010
摘要
Circadian gene transcription is fundamental to metabolic physiology. Here we report that the nuclear receptor REV-ERBα, a repressive component of the molecular clock, forms circadian condensates in the nuclei of mouse liver. These condensates are dictated by an intrinsically disordered region (IDR) located in the protein’s hinge region which specifically concentrates nuclear receptor corepressor 1 (NCOR1) at the genome. IDR deletion diminishes the recruitment of NCOR1 and disrupts rhythmic gene transcription in vivo. REV-ERBα condensates are located at high-order transcriptional repressive hubs in the liver genome that are highly correlated with circadian gene repression. Deletion of the IDR disrupts transcriptional repressive hubs and diminishes silencing of target genes by REV-ERBα. This work demonstrates physiological circadian protein condensates containing REV-ERBα whose IDR is required for hub formation and the control of rhythmic gene expression.
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