正电子发射断层摄影术
磁共振成像
单光子发射计算机断层摄影术
分子成像
中枢神经系统
医学
临床前影像学
发射计算机断层扫描
神经影像学
功能成像
放射科
病理
体内
生物
内科学
生物技术
精神科
作者
Swati Shah,Mitchell L. Turner,Xueyi Chen,Beau M. Ances,Dima A. Hammoud,Elizabeth W. Tucker
标识
DOI:10.1093/infdis/jiad223
摘要
Abstract Central nervous system (CNS) infections can lead to high mortality and severe morbidity. Diagnosis, monitoring, and assessing response to therapy of CNS infections is particularly challenging with traditional tools, such as microbiology, due to the dangers associated with invasive CNS procedures (ie, biopsy or surgical resection) to obtain tissues. Molecular imaging techniques like positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging have long been used to complement anatomic imaging such as computed tomography (CT) and magnetic resonance imaging (MRI), for in vivo evaluation of disease pathophysiology, progression, and treatment response. In this review, we detail the use of molecular imaging to delineate host-pathogen interactions, elucidate antimicrobial pharmacokinetics, and monitor treatment response. We also discuss the utility of pathogen-specific radiotracers to accurately diagnose CNS infections and strategies to develop radiotracers that would cross the blood-brain barrier.
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