化学
生物高聚物
溶解度
生物相容性
环糊精
药品
药物输送
组合化学
纳米技术
药理学
材料科学
聚合物
有机化学
医学
作者
Chandrakantsing V. Pardeshi,Rucha V. Kothawade,Ashwini R. Markad,Sagar R. Pardeshi,Abhijeet D. Kulkarni,Prashant Chaudhari,Marcela Raquel Longhi,Namdev Dhas,Jitendra Naik,Sanjay J. Surana,Monica C. Garcia
标识
DOI:10.1016/j.carbpol.2022.120347
摘要
Sulfobutylether β-cyclodextrin (SBE-β-CD) is a polyanionic cyclic oligosaccharide that contains glucopyranose units forming a torus ring-like structure. SBE-β-CD is gifted with many favorable properties viz. relatively high solubility (>50 folds compared to β-CD), improved stability, and biocompatibility that praised SBE-β-CD as a smart polymer for drug delivery applications. Commercially, SBE-β-CD is popular by its brand name Captisol®. The present review discusses the structure, properties, and preparation methods of SBE-β-CD-based inclusion complexes (ICs). Furthermore, we discuss here the preparation and applications of SBE-β-CD ICs-based nanoparticulate drug delivery systems, which combines the merits of both, ICs (enhanced solubility) and nanoparticles (NPs, targeted therapy). Patents on and FDA-approved Captisol®-enabled products are tabulated in the benefit of readers. The toxicological aspects and current clinical status of SBE-β-CD or SBE-β-CD-based products are briefly explained in the present review. In our opinion, the present review would be a pathfinder to allow dissemination of information on SBE-β-CD.
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