The article examines the processes of formation, transmission and use information in systems of various purposes. The theory is based only on existing ones facts of real life, which are experimentally confirmed by the research of biologists and microbiologists. Since only living systems can be the primary source of information for all artificial systems, much attention is paid to the description of the functioning of biological mechanisms. All living systems have a genome, which is the information that allows organisms to reproduce, without which life would be doomed. It is shown how information perceived by information systems appears. The issue of combining information systems in cybernetics and living nature is considered. It has been proven that information cannot arise without the participation of an information system in which the information must be embedded. This indicates the impossibility of information formation in the presence of only matter and energy.