A Hitchhiker’s Guide to Antibody-Mediated Rejection

Antibody-mediated rejection is an important determinant of allograft survival. Our understanding of antibody-mediated rejection has increased dramatically since the era when only hyperacute antibody-mediated rejection was known. Subacute, acute, and slowly progressive antibody-mediated rejection were subsequently recognized. Many aspects regarding the diagnosis and grading of allograft rejection have been developed through the Banff Classification of Allograft Pathology, an international consensus classification system for the reporting of biopsy specimens obtained from patients with solid-organ transplants. Since its 1991 inception, the Banff Classification of Renal Allograft Pathology has undergone review every 2 years. The diagnosis of antibody-mediated kidney allograft rejection is based . . .