TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway

INTRODUCTIONS: Osteoarthritis (OA) is a significant contributor to disability in the elderly population. However, current therapeutic options are limited. The transient receptor potential melastatin 2 (TRPM2) is involved in a range of disease processes, yet its role in OA remains unclear. OBJECTIVES: To investigate the role of TRPM2 in OA. METHODS: chelation with BAPTA-AM for the treatment of osteoarthritis (OA) was investigated. RESULTS: axis with BAPTA-AM effectively attenuated established OA. CONCLUSIONS: , mtDNA, cGAS, STING, and NF-κB in OA chondrocytes. This suggests that disrupting this loop could be a viable therapeutic approach for OA.