Gut microbiota modulation via fecal microbiota transplantation mitigates hyperoxaluria and calcium oxalate crystal depositions induced by high oxalate diet

草酸钙 草酸盐 生物 粪便细菌疗法 肠道菌群 粪便 移植 草酸钙晶体 内科学 微生物学 内分泌学 生物化学 泌尿系统 化学 医学 抗生素 无机化学 艰难梭菌
作者
Lingyue An,Shujue Li,Zhenglin Chang,Min Lei,Zhican He,Peng Xu,Shike Zhang,Zheng Jiang,Muhammad Sarfaraz Iqbal,Xin‐Yuan Sun,Hongxing Liu,Xiaolu Duan,Wenqi Wu
出处
期刊:Gut microbes [Landes Bioscience]
卷期号:17 (1) 被引量:4
标识
DOI:10.1080/19490976.2025.2457490
摘要

Hyperoxaluria, including primary and secondary hyperoxaluria, is a disorder characterized by increased urinary oxalate excretion and could lead to recurrent calcium oxalate kidney stones, nephrocalcinosis and eventually end stage renal disease. For secondary hyperoxaluria, high dietary oxalate (HDOx) or its precursors intake is a key reason. Recently, accumulated studies highlight the important role of gut microbiota in the regulation of oxalate homeostasis. However, the underlying mechanisms involving gut microbiota and metabolite disruptions in secondary hyperoxaluria remain poorly understood. Here, we investigated the therapeutic efficacy of fecal microbiota transplantation (FMT) sourced from healthy rats fed with standard pellet diet against urinary oxalate excretion, renal damage and calcium oxalate (CaOx) crystal depositions via using hyperoxaluria rat models. We observed dose-dependent increases in urinary oxalate excretion and CaOx crystal depositions due to hyperoxaluria, accompanied by significant reductions in gut microbiota diversity characterized by shifts in Ruminococcaceae_UCG-014 and Parasutterella composition. Metabolomic analysis validated these findings, revealing substantial decreases in key metabolites associated with these microbial groups. Transplanting microbes from healthy rats effectively reduced HDOx-induced urinary oxalate excretion and CaOx crystal depositions meanwhile restoring Ruminococcaceae_UCG-014 and Parasutterella populations and their associated metabolites. Furthermore, FMT treatment could significantly decrease the urinary oxalate excretion and CaOx crystal depositions in rat kidneys via, at least in part, upregulating the expressions of intestinal barrier proteins and oxalate transporters in the intestine. In conclusion, our study emphasizes the effectiveness of FMT in countering HDOx-induced hyperoxaluria by restoring gut microbiota and related metabolites. These findings provide insights on the complex connection between secondary hyperoxaluria caused by high dietary oxalate and disruptions in gut microbiota, offering promising avenues for targeted therapeutic strategies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
苏卿发布了新的文献求助30
2秒前
yyds2222发布了新的文献求助10
2秒前
卿卿发布了新的文献求助10
2秒前
cwqcqw完成签到,获得积分10
3秒前
小李攻攻发布了新的文献求助10
4秒前
einspringen发布了新的文献求助10
4秒前
唐海蓉完成签到 ,获得积分10
5秒前
cwqcqw发布了新的文献求助10
6秒前
6秒前
天天快乐应助111采纳,获得10
6秒前
6秒前
彭于晏应助食化狂徒采纳,获得10
6秒前
7秒前
淘朕朕发布了新的文献求助30
7秒前
chr完成签到 ,获得积分10
8秒前
10秒前
11秒前
洁净的香之完成签到,获得积分10
11秒前
12秒前
lll发布了新的文献求助10
12秒前
12秒前
玩命的化蛹完成签到,获得积分10
14秒前
李健的小迷弟应助水杨酸采纳,获得10
15秒前
艺阳发布了新的文献求助10
15秒前
16秒前
16秒前
17秒前
CAOHOU应助康园采纳,获得10
17秒前
郭1994发布了新的文献求助10
17秒前
111发布了新的文献求助10
18秒前
20秒前
酷波er应助wrong采纳,获得10
20秒前
jiajiajai完成签到,获得积分10
20秒前
21秒前
蒲云海发布了新的文献求助100
21秒前
一碗冷的粥发布了新的文献求助100
23秒前
24秒前
24秒前
Lucas应助自由的馒头采纳,获得10
24秒前
高分求助中
【请各位用户详细阅读此贴后再求助】科研通的精品贴汇总(请勿应助) 10000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
International Code of Nomenclature for algae, fungi, and plants (Madrid Code) (Regnum Vegetabile) 500
Maritime Applications of Prolonged Casualty Care: Drowning and Hypothermia on an Amphibious Warship 500
Comparison analysis of Apple face ID in iPad Pro 13” with first use of metasurfaces for diffraction vs. iPhone 16 Pro 500
Towards a $2B optical metasurfaces opportunity by 2029: a cornerstone for augmented reality, an incremental innovation for imaging (YINTR24441) 500
Materials for Green Hydrogen Production 2026-2036: Technologies, Players, Forecasts 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4056230
求助须知:如何正确求助?哪些是违规求助? 3594329
关于积分的说明 11419977
捐赠科研通 3320180
什么是DOI,文献DOI怎么找? 1825613
邀请新用户注册赠送积分活动 896656
科研通“疑难数据库(出版商)”最低求助积分说明 817971