Comparative efficacy of once daily parnaparin and unfractionated heparin in unstable angina pectoris: PRIME CARE study.

Addition of parnaparin to the standard treatment of unstable angina significantly reduced the incidence of combined triple end points of death, myocardial infarction and need for revascularization when compared to unfractionated heparin. This benefit was observed at 7 days as well as at 30 days of follow-up. The incidence of minor bleeding was significantly less in patients treated with parnaparin. Thus, once daily administration of parnaparin 6400 IU as a fixed dose is a safe and effective alternative to unfractionated heparin in the treatment of unstable angina.