B细胞激活因子
B细胞
单核细胞
免疫学
肿瘤坏死因子α
生物
免疫系统
淋巴细胞
抗体
细胞因子
作者
Paul A. Moore,Ornella Belvedere,A. S. Orr,Krystyna Pieri,David W. LaFleur,Ping Feng,Daniel Soppet,Meghan Charters,Reiner Gentz,David C. Parmelee,Yuling Li,Olga Galperina,Judith G. Giri,Viktor Roschke,Bernardetta Nardelli,Jeffrey A. Carrell,Svetlana Sosnovtseva,Wilbert Greenfield,Steven M. Ruben,Henrik S. Olsen,James Fikes,David M. Hilbert
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1999-07-09
卷期号:285 (5425): 260-263
被引量:1071
标识
DOI:10.1126/science.285.5425.260
摘要
The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS expression on human monocytes could be up-regulated by interferon-γ. Soluble BLyS functioned as a potent B cell growth factor in costimulation assays. Administration of soluble recombinant BLyS to mice disrupted splenic B and T cell zones and resulted in elevated serum immunoglobulin concentrations. The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation.
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