氯喹
恶性疟原虫
IC50型
体外
拉伤
抗疟药
化学
胺气处理
立体化学
药理学
生物
疟疾
生物化学
有机化学
免疫学
解剖
作者
Srinivasarao Kondaparla,Pooja Agarwal,Kumkum Srivastava,Sunil K. Puri,S. B. Katti
摘要
A series of novel bisquinoline compounds comprising N1 -(7-chloroquinolin-4-yl) ethane-1,2-diamine and 7-chloro-N-(2-(piperazin-1-yl)ethyl)quinolin-4-amine connected with 7-chloro-4-aminoquinoline containing various amino acids is described. We have bio-evaluated the compounds against both chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of Plasmodium falciparum in vitro. Among the series, compounds 4 and 7 exhibited 1.8- and 10.6-fold superior activity as compared to chloroquine (CQ; IC50 = 0.255 ± 0.049 μm) against the K1 strain with IC50 values 0.137 ± 0.014 and 0.026 ± 0.007 μm, respectively. Furthermore, compound 7 also displayed promising activity against the 3D7 strain (IC50 = 0.024 ± 0.003 μm) of P. falciparum when compared to CQ. All the compounds in the series displayed resistance factor between 0.57 and 4.71 as against 51 for CQ. These results suggest that bisquinolines can be explored for further development as new antimalarial agents active against chloroquine-resistant P. falciparum.
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