Systems That Allow Diverse Synthesis and Purification Procedures Within an Inert Atmosphere Glovebox

While inert atmosphere gloveboxes greatly facilitate the manipulation and storage of air sensitive materials, standard systems are often unsuitable for synthesis and purification procedures. A variety of apparatus and techniques have been developed to allow otherwise complex or hazardous procedures to be performed entirely inside a glovebox. These include a recirculating inert liquid heat exchange system to provide localized cooling for high temperature processes and a refrigerated immersion probe feedthrough for low temperature operations and for the condensation and removal of solvent vapors. In addition, a compact system for preparative liquid chromatography is described, together with feedthroughs and procedures for direct anaerobic transfer of liquids into and out of a glovebox.