Different platforms used in proteome profiling and quantitative proteomics. 2D-DiGE, two-dimensional differential gel-proteomics; 2-DE, two-dimensional gel electrophoresis; SILAC, stable isotope labeling with amino acids in cell culture; iTRAQ, isobaric tag for relative and absolute quantitation; DDA, data dependent analysis; DIA, data independent analysis; SWATH, Sequential window acquisition of all theoretical fragment ion spectra.* Proteomics methods performed previously on EPM.