On 'Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase' by Yasuhisa Kono

This commentary describes a highly cited paper by Yasuhisa Kono that appeared in Archive. Biochem. Biophys. He established the basic mechanism that involves the autooxidation of hydroxylamine for the assay of superoxide dismutase activity and contributed to the development and progress that has been made in the enzyme assay systems.