Loco Intoxication: Indolizidine Alkaloids of Spotted Locoweed ( Astragalus lentiginosus )

The indolizidine alkaloids swainsonine and swainsonine N -oxide have been isolated and identified as constituents of spotted locoweed. The inhibition of lysosomal α-mannosidase by these alkaloids suggests that they are the causative agents of locoism in range animals.