胸膜肺炎
肺炎
酶学的
猪肺炎支原体
肺
微生物学
胸膜肺炎放线杆菌
免疫学
环氧合酶
生物
白三烯
发病机制
酶
病理
医学
生物化学
血清型
内科学
哮喘
病毒
作者
Roberto Giacominelli-Stuffler,Giuseppe Marruchella,Maria Maddalena Storelli,Annalaura Sabatucci,Clotilde B. Angelucci,Mauro Maccarrone
标识
DOI:10.1016/j.rvsc.2012.01.013
摘要
Enzootic pneumonia by Mycoplasma hyopneumoniae and pleuropneumonia by Actinobacillus pleuropneumoniae are among the most common and economically relevant pulmonary diseases in swine herds. We herein investigated the activity and expression of 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) in healthy and diseased porcine lungs, by means of immunohistochemical, immunochemical and biochemical assays. Diseased lungs showed a significantly higher activity and expression of 5-LOX and COX-2 in a wide range of cell types, thus suggesting the likely involvement of both enzymes in the pathogenesis of bacterial porcine pneumonia. Consistently, increased enzyme activities were paralleled by increased leukotriene B4 (LTB4), a 5-LOX product and prostaglandin E2 (PGE2), a COX-2 product, content in diseased versus healthy lungs.
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