胶束
喜树碱
共聚物
聚合物
乙二醇
毒品携带者
化学
蒸发
化学工程
乳状液
两亲性
木筏
材料科学
高分子化学
药物输送
有机化学
水溶液
工程类
物理
热力学
作者
Masayuki Yokoyama,Praneet Opanasopit,Teruo Okano,Kumi Kawano,Yoshie Maitani
标识
DOI:10.1080/10611860412331285251
摘要
A water-insoluble anti-cancer agent, camptothecin (CPT) was incorporated to a polymeric micelle carrier system forming from poly(ethylene glycol)-poly(aspartate) block copolymers. Incorporation efficiency and stability were analyzed in correlation with chemical structures of the inner core-forming hydrophobic blocks as well as with incorporation methods. Among three incorporation methods (dialysis, emulsion and evaporation methods), an evaporation method brought about much higher CPT yields with less aggregation than the other two methods. By the evaporation method, CPT was incorporated to polymeric micelles in considerably high yields and with high stability using block copolymers possessing high contents of benzyl and methylnaphtyl ester groups as hydrophobic moieties. This indicates importance of molecular design of the hydrophobic block chain to obtain targeting using polymeric micelle carriers as well as importance of the drug incorporation method.
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