原发性血小板增多症
骨髓增生性疾病
真性红细胞增多症
骨髓纤维化
医学
JAK2 V617F
Janus激酶2
内科学
骨髓
受体
作者
Peter J. Campbell,Anthony R. Green
摘要
The discovery of an identical mutation (V617F) of the JAK2 gene in patients with polycythemia vera, essential thrombocythemia, and myelofibrosis — the principal Philadelphia chromosome–negative myeloproliferative disorders — has greatly advanced our understanding of these conditions. This article reviews the legacy of this discovery and how it has changed our view of the origins, interrelations, and management of the myeloproliferative disorders.
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(2025-6-4)
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