The effect of extrinsic hyaluronic acid on collagen metabolism in experimental wound healing

Objective By detecting the influence of hydroxyproline on collagen metabolism of wound healing of rabbit ear to investigate the inhibition effect of hyaluronic acid on wound healing.Methods Wound healing model were made on the ears of 18 rabbits.They were randomly divided into 2%HA treated-group(groupA),1%HA treated-group(groupB) and normal saline treated-group(groupC).The wound healing time and scare formation were observed and recorded.The wound area skin was obtained at different days after operation.Tissue hydroxyproline was detected.Data was analyzed statisticaly.Results The hydroxyproline content in group A and B were lower than group C(P0.01).The difference between group A and B was also prominent(P0.05).The wound healing time of group A and B were later than group C,the scars also smaller than group C.Conclusion Hyaluronic acid can inhibit the collagen synthesis,delay the wound healing,reduce the scar formation.The dependence relationship between effect and dosage is notable.