Influence of rhBNP on cardiac function and modiator of inflammation in patients with acute heart failure

Objective:To evaluate clinical therapeutic effects of recombinant human brain natriuretic peptide(rhBNP,Xinhuosu)on cardiac function and modiator of inflammation in patients with acute heart failure(AHF).Methods:A total of 90 AHF patients were randomly divided into routine treatment group(n=45)and rhBNP group(n=45,received intravenous injection of rhBNP for 3 dbased on routine treatment).Levels of LVEF and mediator of inflammation:serum hsCRP,interleukin-6(IL-6)were compared between two groups before and after treatment.Results:Compared with routine treatment group after treatment,there was significant increase in LVEF[(42.7±13.1)% vs.(50.9±14.5)%],significant decrease in heart rate[(85.7±17.7)times/min vs.(73.5±16.1)times/min],levels of brain natriuretic peptide[BNP,(1142.6±287.5)ng/L vs.(976.7±235.7)ng/L],hsCRP[(8.45±2.68)mg/L vs.(6.82±2.57)mg/L]and IL-6[(16.07±4.75)pg/L vs.(13.35±4.18)pg/L]in rhBNP group,P0.05all.Conclusion:The rhBNP possesses significant effect on cardiac function and mediator of inflammation in AHF patients.