Objective:To analyze the diagnostic value of CT-guided percutaneous biopsy in the musculoskeletal system.Methods:CT-guided percutaneous biopsy was performed in319patients with musculoskeletal lesions.Results:In273(85.6%)patients,pathologic results were obtained,in29(9.1%)cases,no results of pathology were obtained owing to having not e-nough samples,in17(5.3%)cases,no results were obtained owing to not able to acquire samples.In257cases,pathologic re-sults were obtained subsequently at surgery,in212cases,percutaneous biopsy results were consistent with surgery(82.5%),in45cases(17.5%)the biopsy result s were not consistent with the results of surgery.Conclusion:CT-guided percutaneous biopsy is effective for the diagnosis of musculoskeletal system.Open biopsy can be obviated in the majority of cases.The diagnostic ac-curacy was related to the lesion’s pathologic type.The majority cases of unsuccessful biopsy were in the cystic and sclerotic le-sions.