外胚层
乔丁
神经发育
细胞生物学
原肠化
爪蟾
生物
诺金
细胞命运测定
生物学中的钙
神经褶
钙
胚胎
表皮(动物学)
电压依赖性钙通道
神经板
神经管
胚胎发生
解剖
内科学
骨形态发生蛋白
遗传学
细胞内
转录因子
基因
医学
作者
Catherine Leclerc,Céline Rizzo,Christiane Daguzan,Isabelle Néant,Julie Batut,Benoît Augé,Marc Moreau
出处
期刊:PubMed
日期:2001-01-01
卷期号:195 (3): 327-37
被引量:10
摘要
In amphibian embryos the central nervous system derives from the dorsal region of the ectoderm. Molecular studies led to the formulation of the "neural default model" in which neural development is under the inhibitory control of members of the BMP family. These growth factors also act as epidermis inducers. The neural fate is revealed by factors secreted by the Spemann Organizer such as noggin, chordin, follistatin, Xnr3 and cerberus which act by blocking BMP signalling. We propose a new model for neural cell determination in which a signalling pathway controlled by an increase in intracellular calcium suppresses the epidermis fate and activates the neural fate instead. This increase in calcium is due to an influx through calcium channels of the L-type, expressed in ectodermal cells during gastrulation. The possible involvement of a calcium-dependent phosphatase (calcineurin) to inhibit the epidermis fate and a calcium-calmodulin kinase (CaMkinase II) which activates the neural fate is discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI