Infection and Genotype Analysis of Human Papillomavirus among 2324 Outpatients

Objective To investigate the distribution and major subtypes of human papillomavirus( HPV)infection,and to provide a basis for clinical treatment. Methods The detection of HPV was performed in 2 324 outpatients.Results Among 2 324 cases,1 528 cases of HPV positive accounted for 65. 7%,with 1 314 females( 56. 5%) and 214 males( 9. 2%). In females,the patients aged 30-39 years old showed the highest infection rate( 86. 2%,467/542),which was significantly higher than those in the other groups( P 0. 01). In males,the patients aged 20-29 years old showed the highest infection rate( 54. 9%,96 /175),which was significantly higher than those in the other groups( P 0. 01). The single infection was most common in both females and males,50. 5%( 895 /1 772) and 32. 6%( 180 /552),respectively. The types of HPV35 and HPV43 were not detected. In females,the top 4 high-risk types were HPV16( 26. 9%),HPV52(15.6%),HPV58( 8. 5%) and HPV53( 5. 0%),respectively,while low-risk types were HPV11( 8. 0%) and HPV6( 6. 5%). The most common types in males were HPV11( 40. 5%) and HPV6( 32. 0%). Significant gender difference was observed in the infection rate between high-risk types and low-risk types. Conclusion The HPV infection is sensitive in the particular age,as for 30-39 years old in females while 20-29 years old in males. The types of infection are dominated by single infection,and gender difference can be found in the distribution of HPV subtypes infection.