Expression of Her-2 protein in cervical cancer and its clinical significance

Objective: To detect the expression of Her-2 protein in cervical carcinoma,and explore the related clinical significance.Methods: A total of 60 cases with cervical cancer resection from 2008 January to 2010 January were collected,and were divided into three stages according to TNM stages: 18 cases at Ⅰstage,II 29 cases,Ⅲ13 cases.Normal cervical epithelial tissues in 20 cases were selected as control group.Expression of Her-2 protein was detected in cervical tissue by immunohistochemistry.Results: Her-2 protein was expressed in cervical carcinoma tissues and normal tissues,the positive rate in cervical cancer tissues was 68.3%,significantly higher than those in normal cervical tissue of 20%(P0.01).Positive rates of Her-2 protein at Ⅰ,II,III clinical staging were 44.4%,75.7%,84.6%,there was significant difference in positive rate between different clinical stages(P0.05),with the increase of clinical stage of Her-2 protein expression,the rate of the corresponding was increased(P0.05).Conclusions: Her-2 protein plays a certain role in the development of cervical cancer,and can be used for tumor grading and prognosis.It may also be a potential therapeutic target in cervical cancer,with significant clinical value.